GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs11190604 | 1 | rs4919468 | chr10:102288343 | SEC31B | chr10:102246403-102289636:- | -0.29 | -9.16 | 1.51E-18 | Palmitoleic acid (16:1n-7) plasma levels |
| THCA | cis | rs11190604 | 1 | rs4919469 | chr10:102298855 | SEC31B | chr10:102246403-102289636:- | -0.28 | -8.96 | 7.03E-18 | Palmitoleic acid (16:1n-7) plasma levels |
| THCA | cis | rs11190604 | 1 | rs4919470 | chr10:102298920 | SEC31B | chr10:102246403-102289636:- | -0.28 | -9.08 | 2.85E-18 | Palmitoleic acid (16:1n-7) plasma levels |
| THCA | cis | rs11190604 | 1 | rs4919471 | chr10:102299239 | SEC31B | chr10:102246403-102289636:- | -0.28 | -8.84 | 1.79E-17 | Palmitoleic acid (16:1n-7) plasma levels |
| THCA | cis | rs11190604 | 1 | rs4919472 | chr10:102315864 | SEC31B | chr10:102246403-102289636:- | -0.29 | -9.24 | 8.08E-19 | Palmitoleic acid (16:1n-7) plasma levels |
| THCA | cis | rs9527 | 1 | rs4919690 | chr10:104616500 | AS3MT | chr10:104613967-104661653:+ | 0.29 | 5.01 | 7.86E-7 | Arsenic metabolism |
| THCA | cis | rs9527 | 1 | rs4919690 | chr10:104616500 | C10orf32 | chr10:104613967-104624718:+ | 0.49 | 12.72 | 4.08E-32 | Arsenic metabolism |
| THCA | cis | rs5743030 | 1 | rs4920660 | chr2:190744666 | ASNSD1 | chr2:190526125-190535556:+ | -0.58 | -6.09 | 2.35E-9 | Subcutaneous adipose tissue |
| THCA | cis | rs4924935 | 1 | rs4924935 | chr17:18753870 | FAM18B | chr17:18684582-18710026:+ | -0.3 | -6.87 | 2.01E-11 | Pancreatic cancer |
| THCA | cis | rs4925166 | 1 | rs4925166 | chr17:18210810 | EVPLL | chr17:18281079-18292958:+ | -0.3 | -5.43 | 8.9E-8 | Multiple sclerosis |
| THCA | cis | rs4925166 | 1 | rs4925166 | chr17:18210810 | FAM106A | chr17:18427880-18430160:- | -0.22 | -3.87 | 0.000123 | Multiple sclerosis |
| THCA | cis | rs4925166 | 1 | rs4925166 | chr17:18210810 | FAM18B | chr17:18684582-18710026:+ | -0.15 | -3.43 | 0.000661 | Multiple sclerosis |
| THCA | cis | rs4925166 | 1 | rs4925166 | chr17:18210810 | LOC220594 | chr17:18414577-18445234:- | -0.39 | -6.34 | 5.36E-10 | Multiple sclerosis |
| THCA | cis | rs4925166 | 1 | rs4925166 | chr17:18210810 | TOP3A | chr17:18177235-18218321:- | -0.16 | -3.7 | 0.000242 | Multiple sclerosis |
| THCA | cis | rs4925540 | 1 | rs4925540 | chr1:247214878 | OR2T8 | chr1:248084320-248085256:+ | -0.18 | -3.43 | 0.000647 | Response to taxane treatment (docetaxel) |